ABSTRACT
Background: Pulmonary hypertension is one of the complications of thalassemia
Objective: To determine the frequency of pulmonary hypertension in cases of thalassemia
Methodology: This was a cross sectional study, conducted at Department of Cardiology, Sheikh Zayed Hospital, Rahim Yar Khan from 1st July to 31st December 2017. In this study, cases of thalassemia of age 5 years or more were included. The diagnosed cases of thalassemia irrespective of its type and for at least 1 year in duration were included. They were assessed for echocardiography at same institute and pulmonary hypertension was labelled as yes when pulmonary arterial pressure was more than 35 mmHg. Data was analyzed by using SPSS version 23
Results: In this study there were total 105 cases of thalassemia, out of which 63 [60%] were males and 42 [40%] were females. The mean age of the patients was 9.43+/-3.89 years. The mean ALT was 23.78+/-7.13 [U/L], mean AST and ALP were 26.54+/-8.08 and 75.43+/-21.08[U/L]. Mean serum urea and serum creatinine were13.23+/-3.48 and 0.89+/-0.05[mg/dl]. Pulmonary hypertension was seen in 57 [54.29%] of the cases; observed more in females affecting 24 [57.14%] cases with p value of 0.78. It high in age group more than 12 years where it was seen in 15 [83.33%] out of 18 cases with p value of 0.18. This was also more common in cases with haemoglobin of 7 g/dl or less where it was seen in 20 [66.67%] out of 30 cases with p value of 0.46. Conclusion: Pulmonary hypertension is very common among cases of thalassemia and it is more common among patients of age more than 12 years
ABSTRACT
Background: Camel milk has been widely used as a dietry constituent in desert areas where camels are common. It has also been in use to cure a number of commonly occurring diseases
Objective: To investigate the hepato protective effect of camel milk in antituberculous drugs induced hepatotoxicity in rats
Methodology: This randomized control study was conducted on healthy male albino rats. 24 male albino rats [200-250gms] were obtained from National Institute of Health, Islamabad and kept in animal house of Pharmacology Department, Sheikh Zayed Medical College, Rahim Yar Khan. Rats were divided into 4-groups. Each group consisted of 6 rats. Rats were given nutritionally standard diet and recommended dosage of antituberculous drugs along with recommended quantity of camel milk. Data was entered and assessed by using SPSS version 17
Results: Hepatoprotective effect of camel milk was analyzed by liver function parameters as serum aminotransferases, alkaline phosphatases and lactate dehydrogenases. Data showed that antituberculous drugs given for 30 days developed severe liver damage. In biochemical study, there was significant raise in serum diagnostic liver marker enzyme [ALT, AST, ALP and LDH] levels in ATT treated rats. Coadministration of camel milk and antituberculous drugs led to significantly decreased enzyme levels. [P=0.01]
Conclusion: This study concluded that co-administration of camel milk can reduce the toxicity and damage of liver caused by antituberculous drugs